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Serum Neurofilament Light Chain: A Marker of Nervous System Damage in Myopathies

Purpose: Neurofilament light chain in serum (sNfL) has been suggested as a biomarker for the assessment of neuroaxonal damage. Since NfL are not expressed in muscle, elevated sNfL in patients with primary myopathies suggest additional nervous system involvement. To verify this hypothesis, we measure...

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Principais autores: Annika Saak, Pascal Benkert, Katja Akgün, Eline Willemse, Jens Kuhle, Tjalf Ziemssen, Sandra Jackson, Jochen Schaefer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Neuroscience
Assuntos:
myopathy
serum neurofilament
nervous system involvement
mitochondriopathies
myotonic dystrophies (DM1 and DM2)
facio scapulo humeral dystrophy
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnins.2021.791670/full
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