Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3

Progerin, a permanently farnesylated prelamin A protein in cell nuclei, is potentially implicated in the defenestration of liver sinusoidal endothelial cells (LSECs) and liver fibrogenesis. Autophagy regulates the degradation of nuclear components, called nucleophagy, in response to damage. However,...

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Principais autores:	Yangqiu Bai, Jinying Liu, Xiaoke Jiang, Xiuling Li, Bingyong Zhang, Xiaoying Luo
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2022-12-01
丛编:	Cells
主题:	liver sinusoidal endothelial cell defenestration progerin Sirtuin 1 LC3
在线阅读:	https://www.mdpi.com/2073-4409/11/23/3918
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