Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma

Abstract Background Osteosarcoma (OS) shows a multitude of genetic and chromosomal abnormalities together with large biological heterogeneity. These features limited the identification of novel drugs to treat patients with metastases and/or chemo-resistant tumors. The purpose of this study was to cr...

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Hauptverfasser:	Maria Cristina Manara, Francesca Bruzzese, Laura Formentini, Lorena Landuzzi, Laura Pazzaglia, Maria Antonella Laginestra, Marianna Carrabotta, Maria Serena Roca, Federica Iannelli, Laura Grumetti, Laura Addi, Alessandro Parra, Camilla Cristalli, Michela Pasello, Alberto Bavelloni, Francesca Carreras, Francesca Ruzzi, Giuseppe Bianchi, Marco Gambarotti, Alberto Righi, Alfredo Budillon, Pier-Luigi Lollini, Katia Scotlandi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-07-01
Schriftenreihe:	Journal of Experimental & Clinical Cancer Research
Schlagworte:	Osteosarcoma Patient-Derived-Xenografts Drug resistance High-throughput drug screening Ixabepilone
Online-Zugang:	https://doi.org/10.1186/s13046-025-03440-5
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