Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Abstract Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a model system and compared them to colon...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin, Morten Schallburg Nielsen
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2023-11-01
סדרה:	Fluids and Barriers of the CNS
נושאים:	Blood‒brain barrier Receptor-mediated transcytosis Transferrin receptor Sortilin CD133 Podocalyxin
גישה מקוונת:	https://doi.org/10.1186/s12987-023-00480-x
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!