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TusDCB-mediated tRNA sulfur modification is required for virulence and intestinal fitness in enterohemorrhagic Escherichia coli

ABSTRACT Sulfur modification of tRNAs enhances translational accuracy and efficiency, yet its contribution to bacterial pathogenesis remains poorly understood. In Escherichia coli, the TusDCB complex catalyzes 2-thiolation of wobble uridines in lysine-, glutamate-, and glutamine-decoding tRNAs. To i...

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Principais autores: Yumika Sato, Kazutomo Suzue, Hideru Obinata, Mio Horinouchi, Ayako Takita, Mai Maruhashi, Yoji A. Minamishima, Haruyoshi Tomita, Hidetada Hirakawa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-06-01
Serier:Infection and Immunity
Fag:
intestinal infection
bacterial pathogenesis
virulence
tRNA modification
type III secretion system
shiga-toxin producing Escherichia coli
Online adgang:https://journals.asm.org/doi/10.1128/iai.00186-26
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