Iguratimod ameliorated collagen-induced arthritis by suppressing TNF-α/NF-κB signaling pathway and enhancing lymphangiogenesis in a murine model

Abstract Rheumatoid arthritis (RA) is a complex autoimmune joint disease characterized by persistent synovial inflammation and hyperplasia. The TNF-α/NF-κB signaling pathway is one of the most important inflammatory pathways involved in the onset and progression of RA. In addition, impaired lymphati...

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Hlavní autoři:	Minmin Du, Xiaofen Xu, Xiaohui Cui, Yilin Chen, Peng Zhao, Qingqing Hu, Caifeng Wang, Jida Zhang, Guifeng Hao, Changfeng Hu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Scientific Reports
Témata:	Rheumatoid arthritis Inflammation Iguratimod Lymphangiogenesis TNF-α/NF-κB signaling pathway
On-line přístup:	https://doi.org/10.1038/s41598-026-53554-9
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