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Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity

IntroductionLimitation of pharmaceutical application of resveratrol (RSV) and piceatannol (PIC) continue to exist, there is a need to obtain the superior analogs of two stilbenes with promoted activity, stability, and bioavailability. Microbial transformation has been suggested as a common and effic...

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Principais autores: Yu Peng, Yi Huan, Jing-Jing Chen, Tian-Jiao Chen, Lei Lei, Jin-Ling Yang, Zhu-Fang Shen, Ting Gong, Ping Zhu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-03-01
Serier:Frontiers in Microbiology
Fag:
stilbenes
microbial transformation
Beauveria bassiana
methylglucosylation
GPR119 agonist
insulin secretion
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1148513/full
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