Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Background: Malaria elimination and eradication efforts can be advanced by including transmission-blocking or reducing vaccines (TBVs) alongside existing interventions. Key transmission-blocking vaccine candidates, such as Pfs230 domain one and Pfs48/45 domain 3, should be genetically stable to avoi...

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Principais autores:	Kevin O. Ochwedo, Fredrick O. Ariri, Wilfred O. Otambo, Edwin O. Magomere, Isaiah Debrah, Shirley A. Onyango, Pauline W. Orondo, Harrysone E. Atieli, Sidney O. Ogolla, Antony C. A. Otieno, Wolfgang R. Mukabana, Andrew K. Githeko, Ming-Chieh Lee, Guiyun Yan, Daibin Zhong, James W. Kazura
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2022-05-01
叢編:	Frontiers in Genetics
主題:	Pfs230 Pfs48/45 transmission blocking vaccines genetic diversity evolutionary forces
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fgene.2022.867906/full
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