Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis

Abstract Infective endocarditis (IE) is a severe heart infection caused predominantly by Gram-positive bacteria forming biofilm on heart valves. While biofilm formation is central to disease progression, the underlying bacterial mechanisms remain poorly understood. Here, we identify the Fsr quorum s...

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Autores principales:	Haris Antypas, Verena Schmidtchen, Willy Isao Staiger, LI Yanhong, Rachel Jing Wen Tan, Kenneth Kok Fei NG, Cheryl Jia Yi Neo, Shalome Meera Radhesh, Frederick Reinhart Tanoto, Ronni Anderson Gonçalves da Silva, Cristina Colomer-Winter, Sara Doina Schütz, Joachim Kloehn, Logeshwari Muthualagu Natarajan, Caroline Manzano, Jun Jie Wong, Kevin Pethe, Barbara Hasse, Silvio Daniel Brugger, Siu Ling Wong, Daria Van Tyne, Annelies S. Zinkernagel, Kimberly A. Kline
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-68366-8
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