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Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins

Summary: Vascular morphogenesis requires a delicate gradient of Notch signaling controlled, in part, by the distribution of ligands (Dll4 and Jagged1). How Jagged1 (JAG1) expression is compartmentalized in the vascular plexus remains unclear. Here, we show that Jag1 mRNA is a direct target of zinc-f...

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Hoofdauteurs: Hannah L. Sunshine, Andrew C. Cicchetto, Karolina Elżbieta Kaczor-Urbanowicz, Feiyang Ma, Danielle Pi, Chloe Symons, Martin Turner, Vipul Shukla, Heather R. Christofk, Thomas A. Vallim, M. Luisa Iruela-Arispe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2024-01-01
Reeks:Cell Reports
Onderwerpen:
CP: Cell biology
CP: Molecular biology
Online toegang:http://www.sciencedirect.com/science/article/pii/S2211124723016388
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