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Population-specific positive selection on low CR1 expression in malaria-endemic regions

Complement Receptor Type 1 (CR1) is a malaria-associated gene that encodes a transmembrane receptor of erythrocytes and is crucial for malaria parasite invasion. The expression of CR1 contributes to the rosetting of erythrocytes in the brain bloodstream, causing cerebral malaria, the most severe for...

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Auteurs principaux: Paolo Alberto Lorenzini, Elena S. Gusareva, Amit Gourav Ghosh, Nurul Adilah Binte Ramli, Peter Rainer Preiser, Hie Lim Kim
Format: Artigo
Langue:Inglês
Publié: Public Library of Science (PLoS) 2023-01-01
Collection:PLoS ONE
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831336/?tool=EBI
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