The heme A synthase Cox15, as a target of redox-active 3-benzylmenadiones with antiparasitic activity

ABSTRACT Chagas disease, caused by Trypanosoma cruzi, is a neglected parasitic infection. The very limited arsenal of anti-T. cruzi treatments calls for the development of new drugs. Recently, a library of 3-benzylmenadione derivatives was synthesized, with cruzidione being the most efficient and sp...

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Principais autores:	Marcelo L. Merli, Claudia Serot, Cindy Vallières, Julia A. Cricco, Bogdan I. Iorga, Elisabeth Davioud-Charvet, Brigitte Meunier
Formato:	Artigo
Idioma:	Inglês
Publicado:	ASM 2026-01-01
Series:	Antimicrobial Agents and Chemotherapy
Assuntos:	mitochondrial respiratory chain drug mode of action yeast model antiparasitic drug
Acceso en liña:	https://journals.asm.org/doi/10.1128/aac.01161-25
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