Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia

The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML patients, and improved their prognosis. However, TKI resistance is still a major problem with CML patients, reducing th...

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Principais autores:	Xudong Li, Wei Li, Yanli Zhang, Linping Xu, Yongping Song
Formato:	Artigo
Idioma:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2024-09-01
Series:	Genes and Diseases
Assuntos:	Chronic myeloid leukemia Deubiquitinases E3 ligase PROTAC TKI resistance Ubiquitin-proteasome system
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2352304223004336
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