Structural insights into the ubiquitylation strategy of the oligomeric CRL2FEM1B E3 ubiquitin ligase

Abstract Cullin-RING E3 ubiquitin ligase (CRL) family members play critical roles in numerous biological processes and diseases including cancer and Alzheimer’s disease. Oligomerization of CRLs has been reported to be crucial for the regulation of their activities. However, the structural basis for...

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Hlavní autoři:	Zonglin Dai, Ling Liang, Weize Wang, Peng Zuo, Shang Yu, Yaqi Liu, Xuyang Zhao, Yishuo Lu, Yan Jin, Fangting Zhang, Dian Ding, Weiwei Deng, Yuxin Yin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2024-02-01
Edice:	The EMBO Journal
Témata:	Cryo-EM Cullin-RING E3 Ubiquitin Ligase Ubiquitylation Oligomerization
On-line přístup:	https://doi.org/10.1038/s44318-024-00047-y
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