Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five mutations, E35D, two insertions, position 36 (G and S), and D60E. Kinetics, inhibition constants, vitality, Gibbs free binding energies are reported...

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主要な著者:	Sibusiso Maseko, Eden Padayachee, Siyabonga Maphumulo, Thavendran Govender, Yasien Sayed, Glenn Maguire, Johnson Lin, Tricia Naicker, Sooraj Baijnath, Kruger Hendrik Gerhardus
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis Group 2019-01-01
シリーズ:	Journal of Enzyme Inhibition and Medicinal Chemistry
主題:	protease hiv mutant inhibitor thermodynamics
オンライン･アクセス:	http://dx.doi.org/10.1080/14756366.2019.1636234
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