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Involvement of TP53 in osteosarcoma - challenges and prospects

Osteosarcoma (OS), the most common primary malignant bone tumor, remains a therapeutic challenge because of its high metastatic potential, chemoresistance, and poor prognosis. Mutations in the TP53 tumor suppressor gene, including loss-of-function (LOF) and gain-of-function (GOF) mutations, play a c...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yue Shen, Shuzhou Huang, Geng Chen, Guangda Wang, Laijian Sui
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2025-11-01
Rangatū:Frontiers in Oncology
Ngā marau:
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fonc.2025.1605080/full
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