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Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner

Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal...

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Principais autores: Michael MacLean, Judyta Juranek, Swetha Cuddapah, Raquel López-Díez, Henry H. Ruiz, Jiyuan Hu, Laura Frye, Huilin Li, Paul F. Gugger, Ann Marie Schmidt
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-06-01
coleção:Journal of Neuroinflammation
Assuntos:
ALS
Microglia
Neurodegeneration
Macrophage
Astrocytes
RAGE
Acesso em linha:https://doi.org/10.1186/s12974-021-02191-2
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