PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population

ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily dose...

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Principais autores:	Lisa M. Almond, Khaled Abduljalil, Amita Pansari, Beata Kusmider, Hannah M. Jones, Karen Rowland Yeo, Iain Gardner, Muhammad Faisal, Anne Claire Marrast, Myriam El Gaaloul, Jörg J. Möhrle, Nada Abla
格式:	Artigo
语言:	Inglês
出版:	Wiley 2025-04-01
丛编:	CPT: Pharmacometrics & Systems Pharmacology
主题:	lactation malaria physiologically based pharmacokinetics
在线阅读:	https://doi.org/10.1002/psp4.13311
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