Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine

Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain). This study aims to understand the mechanisms that drive a virulent strain to an a...

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Autors principals:	Xumin Ou, Mingshu Wang, Sai Mao, Jingyu Cao, Anchun Cheng, Dekang Zhu, Shun Chen, Renyong Jia, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen, Maikel P. Peppelenbosch, Qiuwei Pan
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-07-01
Col·lecció:	Frontiers in Cellular and Infection Microbiology
Matèries:	Duck hepatitis A virus attenuation RSCU tRNA translational selection vaccine
Accés en línia:	https://www.frontiersin.org/article/10.3389/fcimb.2018.00249/full
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