Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we describe the preclinical and clinical results of a trans...

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Manylion Llyfryddiaeth

Prif Awduron:	Clayton D. Knox, Pieter‐Jan deKam, Karim Azer, Peggy Wong, Antwan G. Ederveen, Diane Shevell, Christopher Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean Francois Denef, Anna Mitselos, Daniel Jonathan, David E. Gutstein, Kaushik Mitra, Shu Yu Sun, Michael Man‐Chu Lo, Doris Cully, Amjad Ali
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2016-09-01
Cyfres:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Pynciau:	blood pressure nitrate nitrate tolerance nitric oxide vasodilation
Mynediad Ar-lein:	https://doi.org/10.1161/JAHA.116.003493
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!