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Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding

<p>Abstract</p> <p>Background</p> <p>The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool for...

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Autors principals: Zhu Zhou, Shi Manli, Hu Wenyue, Estrella Heather, Engebretsen Jon, Nichols Tim, Briere David, Hosea Natilie, Los Gerrit, Rejto Paul A, Fanjul Andrea
Format: Artigo
Idioma:Inglês
Publicat: BMC 2012-07-01
Col·lecció:BMC Genomics
Matèries:
Androgen receptor
ChIP-Seq
Prostate cancer
AR antagonist
Molecular profiling
Accés en línia:http://www.biomedcentral.com/1471-2164/13/355
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