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Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression

Uncontrolled accumulation of pulmonary artery smooth muscle cells (PASMCs) to the distal pulmonary arterioles (PAs) is one of the major characteristics of pulmonary hypertension (PH). Cellular senescence contributes to aging and lung diseases associated with PH and links to PH progression. However,...

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Autori principali: Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-09-01
Serie:Frontiers in Medicine
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Accesso online:https://www.frontiersin.org/articles/10.3389/fmed.2022.908639/full
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