Flexibility in the Insulin Receptor Ectodomain Enables Docking of Insulin in Crystallographic Conformation Observed in a Hormone-Bound Microreceptor

Insulin binding to the insulin receptor (IR) is the first key step in initiating downstream signaling cascades for glucose homeostasis in higher organisms. The molecular details of insulin recognition by IR are not yet completely understood, but a picture of hormone/receptor interactions at one of t...

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Autor principal:	Harish Vashisth
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2014-10-01
coleção:	Membranes
Assuntos:	insulin insulin receptor receptor tyrosine kinases membrane receptors docking molecular dynamics simulations signal transduction
Acesso em linha:	http://www.mdpi.com/2077-0375/4/4/730
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