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Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells

Colon cancer remains a clinical challenge in industrialised countries. Its treatment with 5-Flurouracil (5-FU) develops many side effects and resistance. Thus, several strategies have been undertaken so far, including the use of drug cocktails and polypharmacology. Heme oxygenase-1 (HO-1) is an emer...

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Principais autores: Loredana Salerno, Antonietta Notaro, Valeria Consoli, Federica Affranchi, Valeria Pittalà, Valeria Sorrenti, Luca Vanella, Michela Giuliano, Sebastiano Intagliata
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2024-12-01
Serier:Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:
Hybrids
mutual prodrugs
5-fluorouracil
heme oxygenase 1
HTC116 colorectal cancer cells
Online adgang:https://www.tandfonline.com/doi/10.1080/14756366.2024.2337191
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