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Effects of TNFα on Dynamic Cytosolic Ca2 + and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle

Previously, we reported that in airway smooth muscle (ASM), the cytosolic Ca2+ ([Ca2+]cyt) and force response induced by acetyl choline (ACh) are increased by exposure to the pro-inflammatory cytokine tumor necrosis factor α (TNFα). The increase in ASM force induced by TNFα was not associated with a...

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Principais autores: Young-Soo Han, Philippe Delmotte, Gary C. Sieck
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-07-01
Serier:Frontiers in Physiology
Fag:
inflammatory cytokines
dynamic Ca2+ sensitivity
airway smooth muscle
phase-loop plots
myosin light chain
temporal delay
Online adgang:https://www.frontiersin.org/articles/10.3389/fphys.2021.730333/full
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