Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pair GC-rich tract and the structure of the RT-aptamer...

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Autors principals:	Steve Tuske, Jie Zheng, Erik D. Olson, Francesc X. Ruiz, Bruce D. Pascal, Anthony Hoang, Joseph D. Bauman, Kalyan Das, Jeffrey J. DeStefano, Karin Musier-Forsyth, Patrick R. Griffin, Eddy Arnold
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2020-01-01
Col·lecció:	Current Research in Structural Biology
Matèries:	HDX-MS high-Affinity DNA aptamer HIV-1 reverse transcriptase Subunit-specific 15N-labeling SELEX Integrative structural biology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2665928X20300131
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