Improving polyketide biosynthesis by rescuing the translation of truncated mRNAs into functional polyketide synthase subunits

Abstract Modular polyketide synthases (mPKSs) are multidomain enzymes in bacteria that synthesize a variety of pharmaceutically important compounds. mPKS genes are usually longer than 10 kb and organized in operons. To understand the transcriptional and translational characteristics of these large g...

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Hauptverfasser:	Yan Liu, Chaoyi Song, Qingwen Cui, Hongluan Sun, Chanjuan Jiang, Ruofei Guo, Ruoting He, Zhen Li, Ji Luan, Hailong Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-01-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-025-55973-0
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