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Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis

The pathogenesis of atherosclerosis is defined by impaired lipid handling by macrophages which increases intracellular lipid accumulation. This dysregulation of macrophages triggers the accumulation of apoptotic cells and chronic inflammation which contributes to disease progression. We previously r...

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Principais autores: DuoYao Cao, Suguru Saito, LiMin Xu, Wei Fan, Xiaomo Li, Faizan Ahmed, Predrag Jovanovic, Tomohiro Shibata, Mingtian Che, Ellen A. Bernstein, Jorge Gianni, Ajit S. Divakaruni, Derick Okwan-Duodu, Zakir Khan, Celine E. Riera, Fanfan Chen, Kenneth E. Bernstein
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-10-01
coleção:Frontiers in Immunology
Assuntos:
atherosclerosis
angiotensin converting enzyme (ACE)
monocytes
Ly-6Clo
macrophages
lipid metabolism
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1278383/full
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