Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells

Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium for the ability to induce cell death in a range...

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Detalhes bibliográficos

Principais autores:	Lars Herfindal, Frode Selheim, Stein Ove Døskeland, Øystein Bruserud, Anders Brunsvik, Kolbjørn Zahlsen, Kristin F. Degnes, Knut Teigen, Håvard Sletta, Gro Gausdal, Lene E. Myhren, Gyrid Nygaard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2013-01-01
coleção:	Marine Drugs
Assuntos:	acute myeloid leukemia natural products daunorubicin patient samples
Acesso em linha:	http://www.mdpi.com/1660-3397/11/2/332
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