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ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistance

Abstract Declining mitochondrial function is an established feature of aging and contributes to most aging-related diseases through its impact on various pathologies such as chronic inflammation, fibrosis and cellular senescence. Our recent work suggests that benign prostatic hyperplasia, which is a...

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Hlavní autoři: Teresa T. Liu, Mia J. Carrarini, Livianna K. Myklebust, Kegan O. Skalitzky, Nathalie El-Khoury, Ian J. Sipula, Alexander Chang, Vishal Soman, Ailing Liu, Nnamdi Ihejirika, Uma R. Chandran, Michael J. Jurczak, William A. Ricke, Donald B. DeFranco, Laura E. Pascal
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2025-10-01
Edice:Cell Death and Disease
On-line přístup:https://doi.org/10.1038/s41419-025-08027-8
Tagy: Přidat tag
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