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STING nuclear partners contribute to innate immune signaling responses

Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of STING that increases mobility and redistributes t...

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Principais autores: Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-09-01
Serier:iScience
Fag:
Molecular physiology
Immunology
Virology
Cell biology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004221010233
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