Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes

Dimethyl fumarate (DMF) has emerged as a first-line therapy for relapsing-remitting multiple sclerosis (RRMS). This treatment, however, has been limited by adverse effects, which has prompted development of novel derivatives with improved tolerability. We compared the effects of fumarates on gene ex...

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Bibliografische gegevens

Hoofdauteurs:	William R. Swindell, Krzysztof Bojanowski, Ratan K. Chaudhuri
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2022-04-01
Reeks:	Pharmaceuticals
Onderwerpen:	astrocyte dimethyl fumarate diroximel fumarate glial cells Interferon regulatory factor multiple sclerosis
Online toegang:	https://www.mdpi.com/1424-8247/15/4/461
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