A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims to characterize the impact of Mandarin fish r...

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Auteurs principaux:	Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-02-01
Collection:	Molecular Metabolism
Sujets:	Viral insulin/IGF-1 like peptides (VILPs) IGF-1 Insulin IGF1 receptor IGF1 receptor inhibition Biased signaling
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2212877823001977
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