Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology

Introduction: Fabry disease (FD) results from pathogenic GLA variants, leading to a deficiency in lysosomal α-galactosidase A (α-Gal A) and accumulation of the sphingolipid globotriaosylceramide (Gb3). This leads to severe renal and cardiovascular complications, primarily affecting kidney podocytes....

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Detalhes bibliográficos

Principais autores:	Andrea F. Wise, IGAA Ari Krisnadevi, Shoni Bruell, Han-Chung Lee, Tejasvini Bhuvan, Andrew J. Kassianos, Sheetal Saini, Xiangju Wang, Helen G. Healy, Elizabeth Ling Qian, David A. Elliot, Joel R Steele, Maria Fuller, Kathleen M. Nicholls, Sharon D. Ricardo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-02-01
Colecção:	Kidney International Reports
Assuntos:	ALOX15 Fabry nephropathy Gb3 accumulation GLA variants induced pluripotent stem cells α-Gal A deficiency
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2468024924020461
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