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SL-Cloud: A Cloud-based resource to support synthetic lethal interaction discovery [version 2; peer review: 2 approved]

Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in cancer, as exemplified by the recent success of PARP inhibitors in treating BRCA1/2-deficient tumors. We p...

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Principais autores: William Longabaugh, John Phan, Christopher J. Kemp, David Pot, Guangrong Qin, Bahar Tercan, Boris Aguilar, Taek-Kyun Kim, Ilya Shmulevich, Nyasha Chambwe
Format: Artigo
Sprog:Inglês
Udgivet: F1000 Research Ltd 2022-12-01
Serier:F1000Research
Fag:
synthetic lethality
cloud computing
cancer genomics
cancer dependency
systems biology
functional genomics
eng
Online adgang:https://f1000research.com/articles/11-493/v2
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