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Development and validation of brain target controlled infusion of propofol in mice.

Mechanisms through which anesthetics disrupt neuronal activity are incompletely understood. In order to study anesthetic mechanisms in the intact brain, tight control over anesthetic pharmacology in a genetically and neurophysiologically accessible animal model is essential. Here, we developed a pha...

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Autors principals: Brenna P Shortal, Sarah L Reitz, Adeeti Aggarwal, Qing C Meng, Andrew R McKinstry-Wu, Max B Kelz, Alex Proekt
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2018-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC5912730?pdf=render
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