Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

Summary: Recent clinical studies report that chromosomal 12q24.31 microdeletions are associated with autism spectrum disorder (ASD) and intellectual disability (ID). However, the causality and underlying mechanisms linking 12q24.31 microdeletions to ASD/ID remain undetermined. Here we show Kdm2b, on...

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Autors principals:	Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Adam J. Moeser, George I. Mias, Alfred J. Robison, Yi Zhang, Jin He
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-02-01
Col·lecció:	iScience
Matèries:	Biological sciences Molecular biology Neuroscience
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589004222000128
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