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Vincristine induces somatic segregation, via mitotic crossing-over, in diploid cells of Aspergillus nidulans

Vincristine is an alkaloid widely used as an antineoplastic agent. In eukaryotic cells the drug causes blockage in the G2 phase of the cell cycle and an increase in the frequency of sister chromatid exchanges. Due to the fact that germinating Aspergillus nidulans cells spend most of their cycle in G...

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Main Authors: SIMONE JUREMA RUGGERI CHIUCHETTA, MARIALBA AVEZUM ALVES DE CASTRO-PRADO
Format: Artigo
Language:Inglês
Published: BMC 2002-01-01
Series:Biological Research
Subjects:
aneuploidy
antineoplastic drug
Aspergillus nidulans
recombinagenic activity
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000100006
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