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The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma

Background and AimResearch has shown that green tea catechins may influence the activity of drug metabolizing enzymes and drug transporters. We examined whether epigallocatechin-3-gallate (EGCG) affected the pharmacokinetics and pharmacodynamics of bisoprolol in rats.MethodsA sensitive, specific liq...

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Principais autores: Weiwei Zeng, Sixian Lao, Yi Guo, Yufeng Wu, Min Huang, Brian Tomlinson, Guoping Zhong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-05-01
Serier:Frontiers in Nutrition
Fag:
bisoprolol
epigallocatechin-3-gallate (EGCG)
green tea
pharmacokinetics
pharmacodynamics
hypertension
Online adgang:https://www.frontiersin.org/articles/10.3389/fnut.2022.907986/full
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