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Characterization of Cyclic Peptides for Antituberculosis Drug Development Targeting ClpC1

Drug-resistant <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) remains a major global health challenge, prompting the need for new therapeutics targeting essential bacterial proteins. The caseinolytic protein C1 (ClpC1) is a promising drug target, and accurate measurement of its ATPase activity is cr...

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Principais autores: Robel Demissie, Tasneem M. Vaid, Youngjin Kwon, Gauri Shetye, Thao Tran, Fatema Nomani, Shengnan Jin, Joo-Won Suh, Hanki Lee, Yern-Hyerk Shin, Jinsheng Cui, Dong-Chan Oh, Scott G. Franzblau, Sanghyun Cho, Hyun Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-10-01
Colecção:Applied Sciences
Assuntos:
ClpC1
ATPase assay
assay optimization
SPR
tuberculosis
cyclic peptides
Acesso em linha:https://www.mdpi.com/2076-3417/15/21/11425
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