A droplet microfluidics-based platform for generating target-specific, natively-paired immune libraries and identifying potent and developable antibodies

Abstract The human antibody repertoire is a promising source for therapeutic-grade antibodies. Yet current methods for strategically mining these B cell repertoires are stymied by throughput and chain pairing considerations. This study presents advancements in fluidics and molecular biology that ena...

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Autores principales:	Anusuya Ramasubramanian, Brendan T. Deveney, Sarah A. Clark, Paula Boutin, Kayla Keepseagle, Saleh Riahi, Taotao Lao, Megan Salemi, Sagar Kathuria, Pep Amengual-Rigo, Dilyana Dimova, Leighton Marcovici, Joern Hopke, Jocelyn Newton, Kalie Mix, Kevin Kramer, Hélène Erasimus, Norbert Furtmann, Guillaume Mottet, Nikolai Suslov, Ankit Mahendra, Sambasiva Rao Pemmaraju, Partha S. Chowdhury, David A. Weitz, John A. Heyman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Colección:	Scientific Reports
Acceso en línea:	https://doi.org/10.1038/s41598-025-33040-4
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