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The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis

Abstract Background m6A modification is currently recognized as a major driver of RNA function that maintains cancer cell homeostasis. Long non-coding (Lnc) RNAs control cell proliferation and play an important role in the occurrence and progression of colorectal cancer (CRC). ZCCHC4 is a newly disc...

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Principais autores: Ke Chen, Jingcheng Zhang, Lei Meng, Lingshang Kong, Ming Lu, Zhengguang Wang, Wenbin Wang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-02-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
ZCCHC4
LncRNAGHRLOS
Colorectal cancer
N6-methyladenosine
KDM5D
Acesso em linha:https://doi.org/10.1186/s13046-024-02965-5
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