Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial

Background: Prostate cancer (PCa) progression depends on androgen receptor activity. Cholesterol is required for biosynthesis of all steroid hormones, including androgens. Impact of cholesterol-lowering statins on androgens is unknown. We explored atorvastatin influence on serum and prostatic tissue...

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Principais autores:	Paavo V.H. Raittinen, Heimo Syvälä, Teuvo L.J. Tammela, Merja R. Häkkinen, Pauliina Ilmonen, Seppo Auriola, Teemu J. Murtola
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2021-06-01
Series:	EBioMedicine
Assuntos:	Prostate cancer Serum adrenal androgens Prostatic tissue adrenal androgens Statins Clinical trial
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2352396421002255
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