Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

ABSTRACT Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M. tuberculosis can both synthesize and take up heme, t...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology 2022-10-01
Sarja:	Microbiology Spectrum
Aiheet:	Mycobacterium tuberculosis Mycobacterium smegmatis heme homeostasis iron homeostasis heme synthesis heme
Linkit:	https://journals.asm.org/doi/10.1128/spectrum.03604-22
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