Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

ABSTRACT Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M. tuberculosis can both synthesize and take up heme, t...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-10-01
coleção:	Microbiology Spectrum
Assuntos:	Mycobacterium tuberculosis Mycobacterium smegmatis heme homeostasis iron homeostasis heme synthesis heme
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.03604-22
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!