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DAXX drives de novo lipogenesis and contributes to tumorigenesis

Abstract Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly understood. Using integrated transcriptomic, lipidomic, and molecular studies, here we r...

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Principais autores: Iqbal Mahmud, Guimei Tian, Jia Wang, Tarun E. Hutchinson, Brandon J. Kim, Nikee Awasthee, Seth Hale, Chengcheng Meng, Allison Moore, Liming Zhao, Jessica E. Lewis, Aaron Waddell, Shangtao Wu, Julia M. Steger, McKenzie L. Lydon, Aaron Chait, Lisa Y. Zhao, Haocheng Ding, Jian-Liang Li, Hamsa Thayele Purayil, Zhiguang Huo, Yehia Daaka, Timothy J. Garrett, Daiqing Liao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2023-04-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-37501-0
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