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Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation

The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality. Oxidation has been identified as a prevalent degradation mechanism un...

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Principais autores: Benedykt Kozuch, Johanna Weber, Julia Buske, Karsten Mäder, Patrick Garidel, Tim Diederichs
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-09-01
Serier:Pharmaceutics
Fag:
biotherapeutic formulations
surfactants
polysorbates
polysorbate stability
Tween<sup>®</sup>
autoxidation
Online adgang:https://www.mdpi.com/1999-4923/15/9/2332
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