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Engineered extracellular vesicles with multitargeted anti-microRNA for diabetes-induced cognitive impairment therapy

RNA therapeutics have shown considerable promise in the treatment of various neurological disorders, while their effective delivery across the blood-brain barrier (BBB) and modulation of multiple microRNA pathological targets remains critical challenges. In this study, we developed a dual-engineered...

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Principais autores: Xuetao Chen, Haixiang Sun, Zhicong Zhao, Junyi Che, Yan Bi, Yuanjin Zhao, Jin Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Tsinghua University Press 2026-06-01
coleção:Nano Research
Assuntos:
extracellular vesicle
microrna inhibitor
brain
drug delivery
cognitive impairment
diabetes
Acesso em linha:https://www.sciopen.com/article/10.26599/NR.2026.94908479
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