Single-nucleus transcriptomics illuminates sex differences during murine Escherichia coli pyelonephritis

Abstract There are profound sex differences in the prevalence and outcomes of urinary tract infections (UTI). While females comprise the majority of infections, males exhibit higher morbidity and mortality with upper-tract UTI. Correspondingly, preclinical modeling has demonstrated that male and and...

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Prif Awduron:	Teri N. Hreha, Abigail L. Manson, Christina A. Collins, Haojia Wu, Christophe Georgescu, Benjamin D. Humphreys, Ashlee M. Earl, David A. Hunstad
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-03-01
Cyfres:	Communications Biology
Mynediad Ar-lein:	https://doi.org/10.1038/s42003-026-09946-8
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