Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly

Abstract The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic bottleneck of MAC formation. However, research on blocking the MAC formation of...

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Autors principals:	Min Li, Ningning Wang, Xiaoyan Fu, Gege Wei, Ze Zhang, Yanghan Yu, Tianshui Xue, Yifei Zhao, Jinheng Pan, Dongfeng Wang, Meifang Liu, Yong Li, Jinbao Tang, Longxing Cao, Zhaocheng Jian, Shujuan Liang, Bowen Yu
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-03-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-70667-x
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