Elimination of hepatocyte‐derived DPP4 downregulates cardiac immune‐ and collagen‐related genes but does not alter cardiac function in aged male mice

Abstract The association between metabolic dysfunction–associated steatotic liver disease (MASLD) and cardiovascular disease is well characterized; however, the underlying mechanism is incompletely understood. Interestingly, hepatocyte‐specific silencing of dipeptidyl peptidase 4 (DPP4) prevents liv...

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Autors principals:	Natasha A. Trzaskalski, Melissa M. Dann, Antonio Hanson, Branka Vulesevic, Evgenia Fadzeyeva, Natasha Jeraj, Ilka Lorenzen‐Schmidt, Rick Seymour, Erin E. Mulvihill
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-08-01
Col·lecció:	Physiological Reports
Matèries:	cardiovascular dysfunction diastolic dysfunction dipeptidyl peptidase‐4 echocardiography hepatokine
Accés en línia:	https://doi.org/10.14814/phy2.70453
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